People

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Siân Allerton

PhD Student

I carried out my undergraduate degree in chemistry at Durham University and in my final year I completed an external masters project as part of the Koksch Group at the Freie Universität Berlin. There I focussed on the use of synthetic peptides as effective cell culture platforms. Now, as a member of the Aprile Group, I am looking into the structural and pathological consequences of alpha-synuclein/lipid membrane interactions.

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Ying Ge

Research Associate

Ying completed her BSc and PhD in biochemistry at the University of St Andrews and joined the Arpile group as a post-doctoral research associate in Jan 2021. She is interested in post-translational modifications (PTMs) in amyloid proteins and antibody discovery.

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Dimitra Gialama

Research Associate

Dimitra joined the group in May 2020. She is a chemical engineer with experience in leading innovative biotechnology projects. Currently, she is doing research on neurodegeneration working on antibody discovery for Parkinson’s disease.

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Claudia Lambert

MRes Student

Claudia completed her BS in Chemical Biology at the University of California, Berkeley. She joined the group in December 2021 as an MRes student studying the allosteric sites in the SARS-CoV-2 spike protein. Her project is co-supervised by Professor Sophia Yaliraki.

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Xiaotong (Erin) Lin

MRes Student

Erin joined the group in Oct 2021 as an MRes student in Chemical biology and bio-entrepreneurship. She completed her BSc in Chemistry at King's College London. Her current project focuses on probing Amyloid-β peptide in Alzheimer's disease. Her project is co-supervised by Professor Ramon Vilar.

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Athina Masoura

MSci Student

Athina is an MSci Chemistry Student who joined the group in October 2021. She is interested in the post-translational modifications of amyloid-beta peptides. Her project aims to investigate the acetylation of Lysine 28 and the effects this has on the aggregation of the amyloid-beta peptides in the brain of an Alzheimer's Disease patient. 

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Rebecca Thrush

PhD Student

I completed my undergraduate degree at the University of Cambridge including a masters within the Centre for Misfolding Diseases under the super vision of Dr Janet Kumita. I am now studying for my PhD as part of the Aprile group at Imperial College London, investigating N-terminal post-translational modifications of alpha-synuclein and their role in Parkinson’s disease.

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Devkee Vadukul

Research Associate

Devkee joined the group in 2020 and works primarily on protein misfolding and amyloid formation. Her current project focusses on heterogenous protein aggregation in neurodegenerative diseases. 

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Francesco A. Aprile

Principal Investigator

Francesco is a Lecturer in Chemistry and UKRI Future Leaders Fellow. He obtained his PhD from the University of Milano-Bicocca (Italy) and was previously a Senior Research Fellow of the Alzheimer’s Society in the Department of Chemistry at the University of Cambridge.

Former Group Members

  • 2019-2022 Yiyun Jin (Research Assistant)

  • 2021 Jingzhou Yang (UROP)

  • 2021 Nicole Christou (MRes in Biological and Physical Chemistry)

  • 2020-2021 Joe White (MSci Chemistry)

  • 2019-2020 Michelle Simon (MRes in Drug Discovery and Development)

  • 2017-2019 Shianne Chhangur

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Alexandra Yendrzheyevskiy

MRes Student

Alexandra completed her BSc in Neuroscience at King's College London. Her MRes project focuses on developing antibodies against acetylated amyloid beta peptides.